ea0010dp5 | Diabetes, metabolism and cardiovascular | SFE2005
Nir T
, Melton D
, Dor Y
A fundamental problem in pancreas biology concerns the dynamics of beta cell mass regulation. While autoimmune or pharmacological destruction of beta cells appears to be irreversible, adult beta cell mass does respond to specific physiological cues such as insulin resistance. This raises the exciting possibility that beta cells have a significant regenerative capacity that could be used to treat diabetes. In support of this notion, recent studies in mouse models of diabetes su...